Description

Thermogelling Injectable Hydrogel (Poloxamer-Based System) is formulated using poloxamer (Pluronic) triblock copolymers that exhibit temperature-dependent sol–gel transition behavior. At low temperatures, the system remains in a liquid state, enabling easy handling and injection. Upon exposure to physiological temperature (~37°C), the material rapidly forms a semi-solid hydrogel, allowing localized retention at the target site.

This reversible thermogelling behavior enables minimally invasive delivery with in situ gel formation. The system supports encapsulation of drugs, proteins, and cells, providing a protective and hydrated environment. Gelation temperature and mechanical properties can be tuned by adjusting polymer concentration and formulation parameters.

Key features
Temperature-triggered gelation
Liquid-to-gel transition at physiological temperature
Injectable and minimally invasive
Reversible thermoresponsive behavior
Tunable gelation temperature

Typical specifications
Volume 100 mL
Polymer poloxamer (Pluronic) system
Transition temperature ~30–37°C
State liquid (low temp) → gel (body temp)
Sterility available upon request

Applications
Localized drug delivery
Injectable depots
Wound healing systems
Tissue engineering
Controlled release systems